electron transfer flavoprotein (ETF)

Function: - specific electron acceptor for several dehydrogenases a) 5 acyl-CoA dehydrogenases b) glutaryl-CoA dehydrogenase c) sarcosine dehydrogenase - transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) Structure: - heterodimer of an alpha & a beta subunit Compartment: - mitochondrial matrix Expression: - abundant in liver, heart & skeletal muscle - weak expression is seen in the brain, placenta, lung, kidney & pancreas

General

flavoprotein mitochondrial protein multisubunit protein oxidoreductase

Properties

COMPARTMENT: mitochondrial matrix MOTIF: active site SUBUNITS: electron transfer flavoprotein-alpha subunit MOTIF: Thr phosphorylation site {T42} cofactor-binding site [274-302] COFACTOR-BOUND: flavin adenine dinucleotide electron transfer flavoprotein-beta subunit MOTIF: cofactor-binding site COFACTOR-BOUND: flavin adenine dinucleotide

Database Correlations

OMIM 231675 MORBIDMAP 231675

References

UniProt :accession P13804, P38117

Components

electron transfer flavoprotein-alpha subunit (ETFA) electron transfer flavoprotein-beta subunit (ETFB)