ELAV-like protein 3; Hu-antigen C; HuC; paraneoplastic cerebellar degeneration-associated antigen; paraneoplastic limbic encephalitis antigen 21 (ELAVL3, HUC, PLE21)

Function: - RNA-binding protein - may be involved in neuronal differentiation & maintenance - binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA - may also bind poly-A tracts via RRM 3 Structure: - RRM 1 & RRM 2 bind cooperatively to AU-rich sequences in target mRNAs - RRM 3 binds to poly-A mRNA sequences - belongs to the RRM elav family - contains 3 RRM domain (RNA recognition motif)s Alternative splicing: named isoforms=2 Expression: brain specific Pathology: - autoantigen of paraneoplastic syndromes (anti-Hu antibody)

Related

anti-Hu antibody (type-1 ANNA) cerebellar degeneration related protein paraneoplastic cerebellar degeneration

General

antigen RNA-binding protein

Properties

SIZE: entity length = 367 aa MW = 40 kD MOTIF: RNP motif NAME: RNP motif SITE: 39-117 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 125-205 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 284-362 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

OMIM 603458 UniProt Q14576 Pfam PF00076 Entrez Gene 1995 Kegg hsa:1995

References

UniProt :accession Q14576