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ELAV-like protein 2; Hu-antigen B; HuB; ELAV-like neuronal protein 1; nervous system-specific RNA-binding protein Hel-N1 (ELAVL2, HUB)
Function:
- RNA-binding protein
- seems to recognize a GAAA motif
- binds to 3'untranslated regions of mRNA (its own, c-fos, ID)
- interacts with IGF2BP1
Structure:
- belongs to the RRM elav family
- contains 3 RRM domain (RNA recognition motif)s
Alternative splicing: named isoforms=2
Expression: brain; neural-specific
Pathology:
- autoantigen of paraneoplastic syndromes (anti-Hu antibody)
Related
anti-Hu antibody (type-1 ANNA)
cerebellar degeneration related protein
paraneoplastic cerebellar degeneration
General
antigen
phosphoprotein
RNA-binding protein
Properties
SIZE: entity length = 359 aa
MW = 40 kD
MOTIF: RNP motif
NAME: RNP motif
SITE: 39-117
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
RNP motif
NAME: RNP motif
SITE: 125-205
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Ser phosphorylation site {S221}
RNP motif
NAME: RNP motif
SITE: 276-354
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Database Correlations
OMIM 601673
UniProt Q12926
Pfam PF00076
Entrez Gene 1993
References
UniProt :accession Q12926