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elastase-3B; protease E (ELA3B, CELA3B)
Function:
- efficient protease with alanine specificity but only little elastolytic activity
- preferential cleavage: Ala-|-Xaa
- does not hydrolyze elastin
Structure:
- belongs to the peptidase S1 family, elastase subfamily
- contains 1 peptidase S1 domain
General
elastase
glycoprotein
secreted protein
Properties
SIZE: entity length = 270 aa
MW = 29 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
S1 domain {29-268}
MOTIF: cysteine residue {C58}
MODIFICATION: cysteine residue {C74}
histidine residue {H73}
cysteine residue {C74}
MODIFICATION: cysteine residue {C58}
N-glycosylation site {N114}
cysteine residue {C117}
MODIFICATION: cysteine residue {C120}
cysteine residue {C120}
MODIFICATION: cysteine residue {C117}
aspartate residue {D123}
cysteine residue {C157}
MODIFICATION: cysteine residue {C223}
cysteine residue {C188}
MODIFICATION: cysteine residue {C204}
cysteine residue {C204}
MODIFICATION: cysteine residue {C188}
cysteine residue {C213}
MODIFICATION: cysteine residue {C244}
serine residue {S217}
cysteine residue {C223}
MODIFICATION: cysteine residue {C157}
cysteine residue {C244}
MODIFICATION: cysteine residue {C213}
Database Correlations
UniProt P08861
Pfam PF00089
Entrez Gene 23436
ENZYME 3.4.21.70
References
- UniProt :accession P08861
- Prosite :accession PS00134