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elastase-2B; pancreatic elastase IIB (ELA2B, CELA2B)
Function:
- hydrolysis of elastin
- preferential cleavage: Leu-|-Xaa, Met-|-Xaa & Phe-|-Xaa
Structure:
- belongs to the peptidase S1 family, elastase subfamily
- contains 1 peptidase S1 domain
Compartment: secreted
Expression: pancreas
General
elastase-2; neutrophil elastase; leukocyte elastase; medullasin; bone marrow serine protease ( ELA2, ELANE)
Properties
SIZE: entity length = 269 aa
MW = 29 kD
COMPARTMENT: inner mitochondrial membrane
CELL: neutrophil
erythroblast
MOTIF: signal sequence {1-16}
S1 domain {29-267}
MOTIF: cysteine residue {C58}
MODIFICATION: cysteine residue {C74}
histidine residue {H73}
cysteine residue {C74}
MODIFICATION: cysteine residue {C58}
aspartate residue {D121}
cysteine residue {C155}
MODIFICATION: cysteine residue {C222}
cysteine residue {C186}
MODIFICATION: cysteine residue {C202}
cysteine residue {C202}
MODIFICATION: cysteine residue {C186}
cysteine residue {C212}
MODIFICATION: cysteine residue {C243}
serine residue {S216}
cysteine residue {C222}
MODIFICATION: cysteine residue {C155}
cysteine residue {C243}
MODIFICATION: cysteine residue {C212}
Database Correlations
UniProt P08218
Pfam PF00089
Entrez Gene 51032
ENZYME 3.4.21.71
References
UniProt :accession P08218