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elastase-1; pancreatic elastase 1; chymotrypsin-like elastase family member 1 (ELA1, CELA1)
Function:
- hydrolysis of proteins, including elastin
- preferential cleavage: Ala-|-Xaa
Cofactor: binds 1 Ca+2 per subunit (putative)
Structure:
- belongs to the peptidase S1 family, elastase subfamily
- contains 1 peptidase S1 domain
Compartment: secreted
Expression: skin; not expressed in pancreas
Laboratory:
- pancreatic elastase in body fluid
- pancreatic elastase in serum
- pancreatic elastase free in serum
- pancreatic elastase in stool
General
Ca+2 binding protein
elastase
glycoprotein
Properties
SIZE: entity length = 258 aa
MW = 28 kD
MOTIF: signal sequence {1-8}
S1 domain {19-256}
MOTIF: cysteine residue {C48}
MODIFICATION: cysteine residue {C64}
histidine residue {H63}
cysteine residue {C64}
MODIFICATION: cysteine residue {C48}
Ca+2-binding site
SITE: 77-77
N-glycosylation site {N79}
Ca+2-binding site
SITE: 82-82
Ca+2-binding site
SITE: 87-87
aspartate residue {D111}
cysteine residue {C145}
MODIFICATION: cysteine residue {C212}
cysteine residue {C176}
MODIFICATION: cysteine residue {C192}
cysteine residue {C192}
MODIFICATION: cysteine residue {C176}
cysteine residue {C202}
MODIFICATION: cysteine residue {C232}
serine residue {S206}
cysteine residue {C212}
MODIFICATION: cysteine residue {C145}
cysteine residue {C232}
MODIFICATION: cysteine residue {C202}
N-glycosylation site {N233}
MISC-INFO: INHIBITOR = ALPHA_1_PROTEASE_INHIBITOR
Database Correlations
OMIM 130120
UniProt Q9UNI1
Entrez Gene 1990
ENZYME 3.4.21.36
References
- OMIM :accession 130120 155250
- prosite :accession PS00134
- Wikipedia; Note=Elastase entry
http://en.wikipedia.org/wiki/Elastase