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elafin; elastase-specific inhibitor; ESI; peptidase inhibitor 3; PI-3; protease inhibitor WAP3; skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14 (PI3, WAP3, WFDC14)
Function:
- neutrophil & pancreatic elastase-specific inhibitor of skin
- may prevent elastase-mediated tissue proteolysis
Structure:
- consists of two domains:
- the transglutaminase substrate domain (cementoin moiety) serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins
- elastase inhibitor domain
- contains 1 WAP domain
Compartment: secreted
General
enzyme inhibitor
secreted protein
Properties
COMPARTMENT: extracellular compartment
INHIBITS: elastase
SIZE: entity length = 117 aa
MW = 12 kD
MOTIF: signal sequence {1-22}
2 X tandem repeats of SVP-1 like motif {29-72}
MOTIF: SVP-1 {29-54}
SVP-1 {55-72}
WAP {69-117}
MOTIF: cysteine residue {C76}
MODIFICATION: cysteine residue {C105}
cysteine residue {C83}
MODIFICATION: cysteine residue {C109}
cysteine residue {C92}
MODIFICATION: cysteine residue {C104}
cysteine residue {C98}
MODIFICATION: cysteine residue {C113}
cysteine residue {C104}
MODIFICATION: cysteine residue {C92}
cysteine residue {C105}
MODIFICATION: cysteine residue {C76}
cysteine residue {C109}
MODIFICATION: cysteine residue {C83}
cysteine residue {C113}
MODIFICATION: cysteine residue {C98}
Database Correlations
OMIM 182257
UniProt P19957
PFAM correlations
Entrez Gene 5266
Kegg hsa:5266
References
UniProt :accession P19957