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early growth response protein 4; EGR-4; AT133 (EGR4)

Function: - transcriptional regulator. recognizes & binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG) - activates the transcription of target genes whose products are required for mitogenesis & differentiation (putative) Structure: - belongs to the EGR C2H2-type Zn+2-finger protein family - contains 3 C2H2-type Zn+2 fingers Compartment: nucleus (probable) Expression: induced by PHA/PMA or by serum

General

C2H2 type zinc finger protein early growth response protein family (EGR)

Properties

SIZE: MW = 51 kD entity length = 486 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 380-404 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 410-432 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 438-460 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 128992 UniProt Q05215 Pfam PF00096 Entrez Gene 1961 Kegg hsa:1961

References

  1. UniProt :accession Q05215
  2. Gashler A and Sukhatme VP Early growth response protein 1 (EGR-1): prototype of a zinc- finger family of transcription factors. Prog Nuclei Acid Res Mol Biol 1995, 50:191 PMID: 7754034
  3. Entrez Gene :accession 1961
  4. UniProt :accession Q05215