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early growth response protein 1; EGR-1; protein Krox-24, transcription factor Zif268; nerve growth factor-induced protein A; NGFI-A; transcription factor ETR103; zinc finger protein 225; AT225 (EGR1, ZNF225)
Function:
- transcriptional regulator
- recognizes & binds to the DNA sequence 5'-CGCCCCCGC-3' (EGR-site)
- activates transcription of target genes whose products are required for mitogenesis & differentiation
Structure:
- belongs to the EGR C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression: induced by growth factors
Related
egr1 proto-oncogene, early growth response-1 gene, TIS8, KROX-24, zif-268 or NGF1A
zinc finger protein 225 (ZNF225)
General
C2H2 type zinc finger protein
early growth response protein family (EGR)
Properties
SIZE: entity length = 543 aa
MW = 58 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {57-84}
MOTIF: serine residue (SEVERAL)
Zn finger C2H2-type
SITE: 338-362
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 368-390
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 396-418
EFFECTOR-BOUND: Zn+2
MISC-INFO: LENGTH 533 AMINO_ACID_RESIDUES
Database Correlations
OMIM 128990
UniProt P18146
Pfam PF00096
Entrez Gene 1958
Kegg hsa:1958
References
- Herschman HR
Extracellular signals, transcriptional responses and cellular
specificity
TIBS 14:455 1989
PMID: 2696174
- Gashler A and Sukhatme VP
Early growth response protein 1 (EGR-1): prototype of a zinc-
finger family of transcription factors.
Prog Nuclei Acid Res Mol Biol 1995, 50:191
PMID: 7754034
- Entrez Gene :accession 1958
- UniProt :accession P18146