EGF-like module-containing mucin-like hormone receptor-like 3 (EGF-like module-containing mucin-like receptor EMR3, EMR3)

Function: 1) receptor probably involved in myeloid interactions during immune & inflammatory responses 2) ligand for soluble form of this receptor is present on surface of momocyte-derived macrophages & activated neutrophils Structure: - proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit - forms a heterodimer, consisting of large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) - belongs to the G-protein coupled receptor 2 family, LN-TM7 subfamily - contains 2 EGF-like domains - contains 1 GPS domain Compartment: - cell membrane - subunit alpha may be secreted Alternative splicing: named isoforms=3 Expression: - predominantly leukocyte-restricted expression - highest levels in neutrophils, monocytes, macrophages

General

cell surface receptor glycoprotein transmembrane 7 protein

Properties

SIZE: MW = 73 kD entity length = 652 aa COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-357} MOTIF: signal sequence {1-21} EGF domain {24-66} EGF domain {67-118} N-glycosylation site {N145} N-glycosylation site {N189} N-glycosylation site {N202} N-glycosylation site {N250} N-glycosylation site {N279} GPS {301-350} proteolytic site {338-339} transmembrane domain {358-378} cytoplasmic loop {379-389} transmembrane domain {390-410} exoplasmic loop {411-416} transmembrane domain {417-437} cytoplasmic loop {438-464} transmembrane domain {465-485} exoplasmic loop {486-508} transmembrane domain {509-529} cytoplasmic loop {530-557} transmembrane domain {558-578} exoplasmic loop {579-580} transmembrane domain {581-601} cytoplasmic domain {602-652}

Database Correlations

OMIM 606101 UniProt Q9BY15 PFAM correlations

References

UniProt :accession Q9BY15