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EGF-like domain-containing protein 7 (multiple EGF-like domain protein 7, multiple epidermal growth factor-like domain protein 7, vascular endothelial statin, VE-statin, NOTCH4-like protein, ZNEU1, EGFL7, MEGF7, UNQ187/PRO1449)
Function:
1) regulates vascular tubulogenesis in vivo
2) inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration
3) promotes endothelial cells adhesion to substrate in vitro
Structure:
- contains 2 EGF-like domains
- contains 1 EMI domain
Compartment: secreted
General
EGF-like domain-containing protein (EGFL)
secreted protein
Properties
SIZE: MW = 30 kD
entity length = 273 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
EMI {27-104}
MOTIF: cysteine residue {C31}
MODIFICATION: cysteine residue {C89}
cysteine residue {C56}
MODIFICATION: cysteine residue {C62}
cysteine residue {C62}
MODIFICATION: cysteine residue {C56}
cysteine residue {C88}
MODIFICATION: cysteine residue {C102}
cysteine residue {C89}
MODIFICATION: cysteine residue {C31}
cysteine residue {C102}
MODIFICATION: cysteine residue {C88}
EGF domain {103-135}
MOTIF: cysteine residue {C107}
MODIFICATION: cysteine residue {C117}
cysteine residue {C111}
MODIFICATION: cysteine residue {C123}
cysteine residue {C117}
MODIFICATION: cysteine residue {C107}
cysteine residue {C123}
MODIFICATION: cysteine residue {C111}
cysteine residue {C125}
MODIFICATION: cysteine residue {C134}
cysteine residue {C134}
MODIFICATION: cysteine residue {C125}
EGF domain {137-177}
MOTIF: cysteine residue {C141}
MODIFICATION: cysteine residue {C152}
cysteine residue {C148}
MODIFICATION: cysteine residue {C161}
cysteine residue {C152}
MODIFICATION: cysteine residue {C141}
cysteine residue {C161}
MODIFICATION: cysteine residue {C148}
cysteine residue {C163}
MODIFICATION: cysteine residue {C176}
cysteine residue {C176}
MODIFICATION: cysteine residue {C163}
coiled coil {192-219}
Database Correlations
OMIM 608582
UniProt Q9UHF1
PFAM correlations
References
UniProt :accession Q9UHF1