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EGF-like domain-containing protein 6 (multiple EGF-like domain protein 6, multiple epidermal growth factor-like domain protein 6, MAM & EGF domains-containing gene protein, EGFL6, MAEG, PP648, UNQ281/PRO320)
Function:
- may bind integrin alpha-8/beta-1 & play a role in hair follicle morphogenesis (putative)
Structure:
- belongs to the nephronectin family
- contains 5 EGF-like domains
- contains 1 MAM domain
Compartment: secreted (putative)
Alternative splicing: named isoforms=2
Expression: only detected in fetal tissues
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 553 aa
MW = 61 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
EGF domain {65-91}
EGF domain {94-133}
MOTIF: cysteine residue {C98}
MODIFICATION: cysteine residue {C109}
cysteine residue {C105}
MODIFICATION: cysteine residue {C118}
cysteine residue {C109}
MODIFICATION: cysteine residue {C98}
cysteine residue {C118}
MODIFICATION: cysteine residue {C105}
cysteine residue {C120}
MODIFICATION: cysteine residue {C132}
cysteine residue {C132}
MODIFICATION: cysteine residue {C120}
EGF domain {137-173}
EGF domain {174-212}
MOTIF: cysteine residue {C178}
MODIFICATION: cysteine residue {C191}
cysteine residue {C185}
MODIFICATION: cysteine residue {C200}
cysteine residue {C191}
MODIFICATION: cysteine residue {C178}
cysteine residue {C200}
MODIFICATION: cysteine residue {C185}
EGF domain {219-259}
MOTIF: cysteine residue {C223}
MODIFICATION: cysteine residue {C236}
cysteine residue {C230}
MODIFICATION: cysteine residue {C245}
cysteine residue {C236}
MODIFICATION: cysteine residue {C223}
cysteine residue {C245}
MODIFICATION: cysteine residue {C230}
cysteine residue {C247}
MODIFICATION: cysteine residue {C258}
cysteine residue {C258}
MODIFICATION: cysteine residue {C247}
coiled coil {331-363}
N-glycosylation site {N397}
MAM domain {400-546}
MOTIF: cysteine residue {*1} (2)
MODIFICATION: cysteine residue {*2}
cysteine residue {*2} (2)
MODIFICATION: cysteine residue {*1}
Database Correlations
OMIM 300239
UniProt Q8IUX8
PFAM correlations
References
UniProt :accession Q8IUX8