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ectonucleotide pyrophosphatase/phosphodiesterase family member 7; E-NPP 7; NPP-7; alkaline sphingomyelin phosphodiesterase; intestinal alkaline sphingomyelinase; alk-smase (ENPP7)
Function:
- converts sphingomyelin to ceramide
- also has phospholipase C activity toward palmitoyl lyso-phosphocholine
- does not appear to have nucleotide pyrophosphatase activity
Inhibition:
- dose dependent inhibition by ATP, imidazole, orthovanadate & Zn+2
- not inhibited by ADP, AMP & EDTA
Structure:
- N-glycosylation required for activity & transport to the plasma membrane
- belongs to the nucleotide pyrophosphatase/phosphodiesterase family
Compartment:
- membrane; single-pass type 1 membrane protein (putative)
- localized at the surface of the microvillar membrane in small intestine enterocytes, & in endosome-like structures situated beneath the microvillar membrane, & in Golgi complex
Expression:
- expressed in colon (at protein level)
- expressed in the duodenum, jejunum & liver & at low levels in the ileum
- expression is very low in esophagus, stomach
Pathology:
- decreased levels of ENPP7 may be associated with colorectal carcicinoma
General
glycoprotein
phosphoprotein phosphatase
sphingomyelinase, sphinogomyelin phosphodiesterase
Properties
SIZE: entity length = 458 aa
MW = 51 kD
COMPARTMENT: golgi
MOTIF: signal sequence {1-21}
enzyme activity {72-78}
MOTIF: threonine residue {T75}
N-glycosylation site {N100}
N-glycosylation site {N121}
N-glycosylation site {N146}
N-glycosylation site {N168}
N-glycosylation site {N267}
transmembrane domain {434-454}
STATE: active state
Database Correlations
UniProt Q6UWV6
Pfam PF01663
Entrez Gene 339221
Kegg hsa:339221
ENZYME 3.1.4.12
References
- UniProt :accession Q6UWV6
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/ENPP7ID44055ch17q25.html