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ectoderm-neural cortex protein 1; ENC-1; kelch-like protein 37; nuclear matrix protein NRP/B; p53-induced gene 10 protein (ENC1, KLHL37, NRPB, PIG10)
Function:
- actin-binding protein
- role in regulation of neuronal process formation
- role in differentiation of neural crest cells
- substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
- protein modification; protein ubiquitination
- ubiquitinated & probably targeted for proteasome- independent degradation
- binds to RB1
- hypophosphorylated RB1 associates with ENC1 during neuronal differentiation
- hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells
- part of a complex that contains CUL3, RBX1 & ENC1
Structure:
- contains 1 BTB/POZ domain
- contains 6 kelch repeats
Compartment:
- nucleus matrix. cytoplasm, cytoskeleton
Expression:
- detected in fetal brain tissue
- moderate expression in fetal heart, lung & kidney
- highly expressed in adult brain, particularly high in hippocampus & amygdala
- highly expressed in adult spinal cord
- detected in adult pancreas
- up-regulated upon neuronal differentiation
- induced by TP53/p53
Pathology:
- may be down-regulated in neuroblastoma tumors
General
kelch-like protein
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 589 aa
MW = 66 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: BTB domain {46-114}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
kelch repeat {296-340}
kelch repeat {341-388}
kelch repeat {389-444}
MOTIF: Ser phosphorylation site {S435}
Ser phosphorylation site {S441}
kelch repeat {446-492}
kelch repeat {494-538}
kelch repeat {539-585}
Database Correlations
OMIM 605173
UniProt O14682
PFAM correlations
Entrez Gene 8507
Kegg hsa:8507
References
- UniProt :accession O14682
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/NRPBID40451ch5q12.html