G-protein coupled receptor 183; EBV-induced G-protein coupled receptor 2 (GPR183, EBI2)

Function: - orphan receptor - probable mediator of normal lymphocyte functions - signals constitutively through Gi-alpha, but not Gs-alpha or Gq-alpha Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - expressed abundantly in lymphoid tissues including spleen & lymph node, & in B- & T-lymphocytes - also highly expressed in lung, heart, gastrointestinal tract - weakly expressed in urogenital system & brain - induced by EBV Pathology: - probable mediator of EBV effects on B lymphocytes Note: - uncertain whether Met-1 or Met-5 is the initiator

Properties

SIZE: entity length = 361 aa MW = 41 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-31} transmembrane domain {32-57} cytoplasmic loop {58-77} transmembrane domain {78-95} exoplasmic loop {96-105} MOTIF: cysteine residue {C104} MODIFICATION: cysteine residue {C181} transmembrane domain {106-127} G proteins interaction {126-134} cytoplasmic loop {128-149} transmembrane domain {150-168} exoplasmic loop {169-192} MOTIF: cysteine residue {C181} MODIFICATION: cysteine residue {C104} transmembrane domain {193-215} cytoplasmic loop {216-241} transmembrane domain {242-265} exoplasmic loop {266-287} transmembrane domain {288-312} cytoplasmic domain {313-361}

Database Correlations

OMIM 605741 UniProt P32249 Pfam PF00001 Kegg hsa:1880

References

UniProt :accession P32249