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Ebola monoclonal antibody (ZMapp)
Indications:
- investigational for treatment of Ebola virus
Dosage:
- 3 infusions
- coadministration of oral favipiravir [2]
Mechanism of action:
- cocktail of 3 chimeric monoclonal antibodies targeting the Ebola virus surface glycoprotein [2]
Interactions
drug adverse effects of pharmaceutical monoclonal antibodies
General
antiviral agent
pharmaceutical monoclonal antibody
References
- National Institutes of Health.
News Release. Feb 27, 2015
Liberia-U.S. clinical research partnership opens trial to test
Ebola treatments.
http://www.nih.gov/news/health/feb2015/niaid-27.htm
- The PREVAIL II Writing Group, for the Multi-National
PREVAIL II Study Team.
A randomized, controlled trial of ZMapp for Ebola virus
infection.
N Engl J Med 2016 Oct 13; 375:1448
PMID: 27732819
http://www.nejm.org/doi/10.1056/NEJMoa1604330