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nuclear receptor subfamily 4 group A member 1; early response protein NAK1; nuclear hormone receptor NUR/77; nur77; orphan nuclear receptor HMR; orphan nuclear receptor TR3; ST-59; testicular receptor 3 (NR4A1, GFRP1, HMR, NAK1)
Function:
- orphan nuclear receptor
- interacts with GADD45GIP1
- can interact with DNA as monomer, forms heterodimer with RXR which binds to similar response elements as RAR-RXR
Structure:
- belongs to the nuclear hormone receptor family, NR4 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Expression:
- fetal muscle & adult liver, brain & thyroid
- induced by growth-stimulating agents
General
DNA-binding protein
nuclear hormone receptor NR4 subfamily
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 598 aa
MW = 64 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {82-92}
MOTIF: serine residue (SEVERAL)
DNA-binding motif
SITE: 264-339
MOTIF: Zn finger C4-type
SITE: 267-287
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 303-327
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S341}
Ser phosphorylation site {S351}
binding site
SITE: 409-459
FOR-BINDING-OF: ligand
proline-rich region
SITE: 583-586
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 139139
UniProt P22736
PFAM correlations
Kegg hsa:3164
References
UniProt :accession P22736