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early placenta insulin-like peptide (EPIL, placentin,insulin-like peptide 4, [Contains: Early placenta insulin-like peptide B chain; Early placenta insulin-like peptide A chain], INSL4)
Function:
1) role in trophoblast development (putative)
2) role in regulation of bone formation (putative)
Compartment: secreted
Expression:
- expressed in placenta, uterus & fetal perichondrium
- expression increased early placentas
Pathology:
1) expression increased in molar pregnancies & diminished in choriocarcinoma cells
General
secreted protein
Properties
SIZE: MW = 15 kD
entity length = 139 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
cysteine residue {C31}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C43}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C124}
MODIFICATION: cysteine residue {C129}
cysteine residue {C129}
MODIFICATION: cysteine residue {C124}
Database Correlations
OMIM 600910
UniProt Q14641
References
UniProt :accession Q14641