transcription factor COE3; early B-cell factor 3; EBF-3; olf-1/EBF-like 2; O/E-2; OE-2 (EBF3, COE3)

Function: - transcriptional activator - recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (putative) - forms either a homodimer or a heterodimer with a related family member (putative) Structure: - belongs to the COE family - contains 1 IPT/TIG domain Compartment: nucleus (putative) Alternative splicing: named isoforms=2; long, short Expression: expressed in brain

General

COE family transcription factor human longevity protein

Properties

SIZE: entity length = 596 aa MW = 65 kD COMPARTMENT: cell nucleus MOTIF: DNA interaction {63-66} Zinc finger NAME: Zinc finger SITE: 151-170 EFFECTOR-BOUND: Zn+2 MOTIF: arginine residue {163} asparagine residue {172} DNA interaction {197-204} DNA interaction {236-239} IPT/TIG {263-346} threonine-rich region {464-555} MOTIF: threonine residue (SEVERAL)

Database Correlations

OMIM 607407 UniProt Q9H4W6 Pfam PF01833 Entrez Gene 253738 Kegg hsa:253738

References

UniProt :accession Q9H4W6