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transcription factor COE2; early B-cell factor 2; EBF-2 (,EBF2 COE2)
Function:
- transcription factor
- in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation
- acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway
- recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (putative)
- forms either a homodimer or a heterodimer with a related family member (putative)
Structure:
- belongs to the COE family
- contains 1 IPT/TIG domain
Compartment: nucleus (putative)
General
COE family transcription factor
Properties
SIZE: entity length = 575 aa
MW = 63 kD
COMPARTMENT: cell nucleus
MOTIF: DNA interaction {62-65}
Zinc finger
NAME: Zinc finger
SITE: 150-169
EFFECTOR-BOUND: Zn+2
MOTIF: arginine residue {162}
asparagine residue {171}
DNA interaction {196-203}
DNA interaction {235-238}
IPT/TIG {253-336}
threonine-rich region {453-534}
MOTIF: threonine residue (SEVERAL)
Database Correlations
OMIM 609934
UniProt Q9HAK2
Pfam PF01833
Entrez Gene 64641
Kegg hsa:64641
References
UniProt :accession Q9HAK2