E3 ubiquitin-protein ligase RNF167 (RING finger protein 167, RING105, RNF167)

Function: 1) E3 ubiquitin-protein ligase (putative) - auto-ubiquitinated in vitro in the presence of UBE2D1 & UBE2E1 2) growth regulation involved in G1/S transition 3) ubiquitin conjugation, 3rd step 4) interacts with SLC22A18 Structure: - contains 1 PA domain (protease associated domain) - contains 1 RING-type zinc finger Compartment: membrane, cytoplasmic membrane Expression: expressed in kidney, liver

General

glycoprotein membrane protein ring finger protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: MW = 38 kD entity length = 350 aa COMPARTMENT: cytoplasm MOTIF: signal sequence {1-24} PA {49-152} MOTIF: N-glycosylation site {N79} transmembrane domain {174-194} RING-finger {230-272} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif

Database Correlations

UniProt Q9H6Y7 PFAM correlations ENZYME 6.3.2.-

References

UniProt :accession Q9H6Y7