CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; transcriptional repressor NOT4Hp (CNOT4, NOT4)

Function: - E3 ubiquitin ligase - subunit of the CCR4-NOT core complex - protein modification; protein ubiquitination - autoubiquitinated - phosphorylated upon DNA damage, probably by ATM or ATR - binds CNOT1 via its C-terminus - binds E2 ubiquitin ligases via its RING domain - interacts (via RING domain) with UBE2D2 Structure: - contains 1 C3H1-type Zn⁺² finger - contains 1 RING-type Zn⁺² finger - contains 1 RRM domain (RNA recognition motif) Compartment: - cytoplasm (probable) - nucleus (probable) Alternative splicing: named isoforms=8

General

phosphoprotein protein subunit ring finger protein RNA-binding protein transcriptional silencer (transcriptional repressor) E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: entity length = 575 aa MW = 64 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: RING-finger {14-57} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif coiled coil {68-104} MOTIF: Ser phosphorylation site {S71} RNP motif NAME: RNP motif SITE: 109-189 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Zinc finger NAME: Zinc finger SITE: 190-217 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S324} Ser phosphorylation site {S432} Ser phosphorylation site {S490}

Database Correlations

OMIM 604911 UniProt O95628 Pfam PF00076 Entrez Gene 4850 Kegg hsa:4850

References

UniProt :accession O95628