E3 SUMO-protein ligase NSE2 (non-structural maintenance of chromosomes element 2 homolog, non-SMC element 2 homolog, hMMS21, NSMCE2, C8orf36, MMS21)

Function: - E3 SUMO-protein ligase component of the SMC5-SMC6 complex - acts as a E3 ligase mediating SUMO attachment to various proteins including SMC6L1 & TRAX, & perhaps the cohesin components RAD21 & STAG2 - SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair - SUMO conjugation, 3rd step - sumoylated, possibly via autosumoylation Structure: - belongs to the NSE2 family - contains 1 SP-RING-type zinc finger Compartment: nucleus (probable)

General

ligase or synthetase nuclear protein ring finger protein

Properties

SIZE: MW = 28 kD entity length = 247 aa COMPARTMENT: cell nucleus MOTIF: RING-finger {154-236} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif

References

UniProt :accession Q96MF7