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E2F6.com-1 complex
Function:
- repressive complex that methylates Lys-9 of histone H3
- role in chromatin-remodeling (putative)
Structure:
- consists of: (in G0 phase)
- E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2, YAF2
General
molecular complex
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: transcription factor E2F6
MOTIF: DNA-binding motif
SITE: 50-129
MOTIF: Ser phosphorylation site {S67}
DEF box {95-129}
Dimerization {130-222}
MOTIF: leucine zipper
SITE: 143-164
FOR-BINDING-VIA: leucine zipper
silencer element
SITE: 173-281
MOTIF: glutamate-rich region {265-268}
MOTIF: glutamate residue (SEVERAL)
MAX gene-associated protein
COMPARTMENT: cell nucleus
MOTIF: T-box domain
SITE: 84-260
glutamine-rich region {967-981}
MOTIF: glutamine residue (SEVERAL)
coiled coil {1111-1147}
serine-rich region {1255-1263}
MOTIF: serine residue (SEVERAL)
threonine-rich region {1594-1714}
MOTIF: threonine residue (SEVERAL)
DNA-binding motif
SITE: 1876-2383
MOTIF: Ser phosphorylation site {S1973}
helix-loop-helix
NAME: helix-loop-helix
SITE: 2384-2436
FOR-BINDING-VIA: helix-loop-helix
coiled coil {2778-2802}
protein max
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S2}
Ser phosphorylation site {S11}
DNA-binding motif
SITE: 24-36
helix-loop-helix
NAME: helix-loop-helix
SITE: 39-75
FOR-BINDING-VIA: helix-loop-helix
leucine zipper
SITE: 81-102
FOR-BINDING-VIA: leucine zipper
Tyr phosphorylation site {Y123}
nuclear translocation signal {152-156}
transcription factor DP-1
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S23}
DNA-binding motif
SITE: 113-195
MOTIF: DEF box {161-195}
Ser phosphorylation site {S183}
Dimerization {204-277}
binding site
SITE: 211-327
FOR-BINDING-OF: E2F
MOTIF: DCB1 {214-246}
proline-rich region
SITE: 250-253
MOTIF: proline residue (SEVERAL)
DCB2 {259-315}
acidic region {394-410}
MOTIF: acidic residue (SEVERAL)
chromobox protein homolog 3
COMPARTMENT: cell nucleus
MOTIF: chromodomain
NAME: chromodomain
SITE: 30-88
FOR-BINDING-OF: heterochromatin
Ser phosphorylation site {S93}
Ser phosphorylation site {S95}
Ser phosphorylation site {S97}
chromodomain
NAME: chromodomain
SITE: 121-179
FOR-BINDING-OF: heterochromatin
MOTIF: Ser phosphorylation site {S176}
histone-lysine N-methyltransferase EHMT2
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {2-13}
MOTIF: alanine residue (SEVERAL)
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S140}
alanine-rich region {160-163}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S173}
Ser phosphorylation site {S232}
Ser phosphorylation site {S246}
glutamate-rich region {300-326}
MOTIF: glutamate residue (SEVERAL)
Thr phosphorylation site {T555}
Ser phosphorylation site {S569}
ankyrin repeat
NAME: ankyrin repeat
SITE: 649-678
ankyrin repeat
NAME: ankyrin repeat
SITE: 684-713
ankyrin repeat
NAME: ankyrin repeat
SITE: 717-746
ankyrin repeat
NAME: ankyrin repeat
SITE: 750-780
ankyrin repeat
NAME: ankyrin repeat
SITE: 784-813
ankyrin repeat
NAME: ankyrin repeat
SITE: 817-846
MOTIF: H3K9me binding {817-819}
ankyrin repeat
NAME: ankyrin repeat
SITE: 850-879
pre-SET domain {972-1035}
MOTIF: Zn+2-binding site
SITE: 974-974
Zn+2-binding site
SITE: 976-976
Zn+2-binding site
SITE: 980-980
Zn+2-binding site
SITE: 985-985
Zn+2-binding site
SITE: 987-987
Zn+2-binding site
SITE: 1017-1017
Zn+2-binding site
SITE: 1021-1021
Zn+2-binding site
SITE: 1023-1023
Zn+2-binding site
SITE: 1027-1027
SET domain {1037-1159}
MOTIF: SAM binding {1048-1050}
binding site
SITE: 1067-1067
FOR-BINDING-OF: Histone H3K9me
H3 interaction {1074-1093}
binding site
SITE: 1085-1085
FOR-BINDING-OF: S-adenosylmethionine
SAM binding {1112-1113}
Zn+2-binding site
SITE: 1115-1115
H3 interaction {1154-1157}
post-SET domain {1164-1180}
MOTIF: Zn+2-binding site
SITE: 1168-1168
Zn+2-binding site
SITE: 1170-1170
Zn+2-binding site
SITE: 1175-1175
Thr phosphorylation site {T1210}
E3 ubiquitin-protein ligase RING1
COMPARTMENT: cell nucleus
MOTIF: silencer element
SITE: 30-234
MOTIF: Ser phosphorylation site {S38}
RING-finger {48-88}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S187}
Ser phosphorylation site {S188}
Ser phosphorylation site {S190}
nuclear translocation signal {201-204}
glycine-rich region {205-260}
CBX2 interaction {230-406}
MOTIF: glycine-rich region {314-377}
E3 ubiquitin-protein ligase RING2
COMPARTMENT: cell nucleus
MOTIF: HIP2 interaction {1-179}
MOTIF: RING-finger {51-91}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S168}
Ser phosphorylation site {S203}
polycomb group RING finger protein 6
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 22-66
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S30}
glutamate-rich region {63-120}
MOTIF: glutamate residue (SEVERAL)
coiled coil {72-110}
RING-finger {134-173}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Lethal(3)malignant brain tumor-like 2 protein
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {17-20}
MOTIF: glutamate residue (SEVERAL)
Zinc finger
NAME: Zinc finger
SITE: 81-116
EFFECTOR-BOUND: Zn+2
MBT {179-283}
MBT {291-391}
MBT {397-500}
MBT {508-604}
lysine-rich region {620-624}
MOTIF: lysine residue (SEVERAL)
YY1-associated factor 2
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 19-48
EFFECTOR-BOUND: Zn+2
References
UniProt :accession Q8IY57, Q99496
Components
chromobox protein homolog 3; heterochromatin protein 1 homolog gamma; HP1 gamma; modifier 2 protein; HECH (CBX3)
E3 ubiquitin-protein ligase RING1; RING finger protein 1; polycomb complex protein RING1 (RING1, RNF1)
E3 ubiquitin-protein ligase RING2; Huntingtin-interacting protein 2-interacting protein 3; HIP2-interacting protein 3; protein DinG; RING finger protein 1B; RING1b; RING finger protein 2; RING finger protein BAP-1 (RNF2, BAP1, DING, HIPI3, RING1B)
histone-lysine N-methyltransferase EHMT2; euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; lysine N-methyltransferase 1C; protein G9a (EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36)
Lethal(3)malignant brain tumor-like 2 protein; L(3)mbt-like 2 protein; H-l(3)mbt-like protein (L3MBTL2)
MAX gene-associated protein (MGA KIAA0518)
polycomb group RING finger protein 6 (RING finger protein 134, Mel18 & Bmi1-like RING finger, PCGF6, MBLR, RNF134)
protein max; Myc-associated factor X (MAX)
transcription factor DP-1; E2F dimerization partner 1; DRTF polypeptide-1; TFDP1 (DP1, DRTF1)
transcription factor E2F6 (E2F-6, E2F6)
YY1-associated factor 2 (YAF2)