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D site-binding protein (albumin D box-binding protein, albumin D-element-binding protein, TAXREB302, DBP)
Function:
1) transcriptional activator
2) recognizes & binds to sequence 5'-RTTAYGTAAY-3' found in promoter of albumin, CYP2A4 & CYP2A5 genes
3) modulates clock output genes, but not essential for circadian rhythm generation
4) regulation by circadian pacemaker component clock (putative)
5) role in circadian period & sleep regulation.
6) binds DNA as a homodimer or a heterodimer
7) forms heterodimer with TEF
Structure:
1) belongs to the bZIP family, PAR subfamily
2) contains 1 bZIP domain
Compartment: nucleus
Expression:
- ubiquitously expressed
- expressed in the suprachiasmatic nuclei (SCN) & in most peripheral tissues, in a circadian rhythm
General
DNA-binding protein
Properties
SIZE: MW = 34 kD
entity length = 325 aa
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 129-135
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 188-239
MOTIF: proline residue (SEVERAL)
DNA-binding motif
SITE: 258-277
leucine zipper
SITE: 290-304
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 124097
UniProt Q10586
Pfam PF07716
References
UniProt :accession Q10586