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D-aspartate oxidase (DASOX, DDO)
Function:
- selectively catalyzes oxidative deamination of D-aspartate & its N-methylated derivative, N-methyl D-aspartate
D-aspartate + H2O + O2 oxaloacetate + NH3 + H2O2
Cofactor: FAD or 6-hydroxyflavin adenine dinucleotide
Structure:
- belongs to the DAMOX/DASOX family
Compartment: peroxisome
Alternative splicing: named isoforms=2
General
flavoprotein
oxidoreductase
Properties
SIZE: MW = 38 kD
entity length = 341 aa
MOTIF: cofactor-binding site [6-20]
COFACTOR-BOUND: flavin adenine dinucleotide
tyrosine residue {Y223}
histidine residue {H302}
microbody-targeting signal {339-341}
Database Correlations
OMIM 124450
UniProt Q99489
Pfam PF01266
ENZYME 1.4.3.1
References
UniProt :accession Q99489