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dyslexia susceptibility 1 candidate gene 1 protein (DYX1C1, EKN1)
Structure:
- contains 1 CS domain contains 3 TPR repeats
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in brain, lung, kidney, testis
- in brain localizes to a fraction of cortical neurons & white matter glial cells
Pathology:
- chromosomal translocation t(2;15)(q11;q21) involving DYX1C1 may be a cause of dyslexia
General
nuclear protein
Properties
SIZE: MW = 48 kD
entity length = 420 aa
COMPARTMENT: cell nucleus
MOTIF: CS {3-87}
tetratricopeptide repeat {290-323}
tetratricopeptide repeat {324-357}
tetratricopeptide repeat {366-399}
Database Correlations
OMIM correlations
MORBIDMAP 608706
UniProt Q8WXU2
PFAM correlations
References
UniProt :accession Q8WXU2