dysfibrinogenemia

Etiology: hereditary disorder Epidemiology: 1) uncommon 2) 1% of patients with thrombosis Laboratory: 1) low plasma fibrinogen by thrombin clotting method (50-130 mg/dL) 2) prolonged dilute thrombin time Management: 1) anticoagulation 2) cryoprecipitate (as a source of fibrinogen) during surgery or following trauma

General

genetic disease of the blood/bone marrow hypercoagulability

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998