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dual specificity tyrosine-phosphorylation-regulated kinase 3; regulatory erythroid kinase; REDK (DYRK3)
Function:
- negative regulator of EPO-dependent erythropoiesis
- may place an upper limit on red cell production during stress erythropoiesis
- inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells
- may act by regulating CREB/CRE signaling
- autophosphorylated on Tyr
Cofactor: Mg+2 (putative)
Structure:
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
- contains 1 protein kinase domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- isoform 1 & isoform 2 are highly expressed in testis & in hematopoietic tissue such as fetal liver, & bone marrow
- isoform 2 is the predominant form in testis
- isoform 1 is the predominant form in fetal liver & bone marrow
- isoform 1 & isoform 2 are present at low levels in heart, pancreas, lymph node, & thymus
- induced by EPO/erythropoietin
General
dual-specificity tyrosine-phosphorylation regulated kinase
nuclear protein
Properties
SIZE: entity length = 588 aa
MW = 66 kD
COMPARTMENT: cell nucleus
MOTIF: kinase domain
SITE: 209-522
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 215-223
Tyr phosphorylation site {Y209}
ATP-binding site
NAME: ATP-binding site
SITE: 238-238
Ser phosphorylation site {S318}
aspartate residue {D335}
Tyr phosphorylation site {Y369}
STATE: active state
Database Correlations
OMIM 603497
UniProt O43781
Pfam PF00069
Entrez Gene 8444
Kegg hsa:8444
ENZYME 2.7.12.1
References
UniProt :accession O43781