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dual specificity protein phosphatase CDC14B; CDC14 cell division cycle 14 homolog B (CDC14B)
Function:
- dual-specificity phosphatase involved in DNA damage response
- essential regulator of the G2 DNA damage checkpoint:
- following DNA damage, translocates from the nucleolus to the nucleoplasm & dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C)
- dephosphorylation of FZR1/CDH1 activates the cyclosome, leading to ubiquitination of PLK1, preventing entry into mitosis
- preferentially dephosphorylates proteins modified by proline-directed kinases
- interacts with FZR1/CDH1
Structure:
- composed of two structurally equivalent A & B domains that adopt a dual specificity protein phosphatase (DSP) fold
- belongs to the protein-tyrosine phosphatase family non-receptor class CDC14 subfamily
Compartment:
- nucleus, nucleolus, nucleoplasm
- following DNA damage, translocates from the nucleolus to the nucleoplasm & interacts with FZR1/CDH1
- nucleolus during interphase
Alternative splicing: named isoforms=4
General
dual specificity phosphatase
nuclear protein
Properties
SIZE: entity length = 498 aa
MW = 57 kD
COMPARTMENT: cell nucleus
MOTIF: nucleolar localization signal {1-54}
A {44-198}
Linker {199-212}
B {213-379}
MOTIF: cysteine residue {C314}
STATE: active state
Database Correlations
OMIM 603505
UniProt O60729
Pfam PF00782
Entrez Gene 8555
Kegg hsa:8555
ENZYME correlations
References
- UniProt :accession O60729
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc14b/