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dual specificity protein phosphatase CDC14A; CDC14 cell division cycle 14 homolog A (CDC14A)
Function:
- dual-specificity phosphatase
- required for centrosome separation & productive cytokinesis during cell division
- may dephosphorylate the cyclosome subunit FZR1/CDH1, thus promoting cyclosome-FZR1 dependent degradation of mitotic cyclins & subsequent exit from mitosis
- interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle
Structure:
- composed of two structurally equivalent A & B domains that adopt a dual specificity protein phosphatase (DSP) fold
- belongs to the protein-tyrosine phosphatase family non-receptor class CDC14 subfamily
Compartment:
- nucleus, cytoplasm, cytoskeleton, centrosome
- cytoskeleton, spindle
- centrosomal during interphase
- released into the cytoplasm at the onset of mitosis
- subsequently localizes to the midzone of the mitotic spindle
Alternative splicing: named isoforms=4
General
dual specificity phosphatase
nuclear protein
Properties
SIZE: entity length = 594 aa
MW = 67 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: A {7-162}
Linker {163-176}
B {177-343}
MOTIF: cysteine residue {C278}
STATE: active state
Database Correlations
OMIM 603504
UniProt Q9UNH5
Pfam PF00782
Entrez Gene 8556
Kegg hsa:8556
ENZYME correlations
References
- UniProt :accession Q9UNH5
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc14a/