dual specificity protein phosphatase 21; low molecular weight dual specificity phosphatase 21; LMW-DSP21 (DUSP21, LMWDSP21)

Function: - can dephosphorylate single & diphosphorylated synthetic MAPK peptides, with preference for the phospho-Tyr & diphosphorylated forms over phospho-Thr Structure: - belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily - contains 1 tyrosine-protein phosphatase domain Compartment: - cytoplasm, nucleus, mitochondrial inner membrane - peripheral membrane, matrix side Expression: expressed in testis

General

dual specificity phosphatase nuclear protein

Properties

SIZE: entity length = 190 aa MW = 22 kD COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: Tyr phosphatase {21-161} MOTIF: domain {43-128} cysteine residue {C106} active site MOTIF: HC motif STATE: active state

Database Correlations

OMIM 300678 UniProt Q9H596 Pfam PF00782 Entrez Gene 63904 Kegg hsa:63904 ENZYME correlations

References

UniProt :accession Q9H596