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dual specificity protein kinase TTK; phosphotyrosine picked threonine-protein kinase; PYT (TTK, MPS1, MPS1L1)
Function:
- phosphorylates proteins on Ser, Thr, & Tyr
- probably associated with cell proliferation
- essential for chromosome alignment by enhancing AURKB activity (via CDCA8 phosphorylation) at the centromere, & for the mitotic checkpoint
Inhibition:
- inhibited by the ATP-competitive kinase inhibitor, SP600125
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family
- contains 1 protein kinase domain
Expression:
- present in rapidly proliferating cell lines
General
serine/threonine kinase
tyrosine kinase (protein tyrosine kinase, PTK)
Properties
SIZE: entity length = 857 aa
MW = 97 kD
STATE: active state
MOTIF: Ser phosphorylation site {S3}
Ser phosphorylation site {S7}
Thr phosphorylation site {T33}
Ser phosphorylation site {S37}
Ser phosphorylation site {S49}
Ser phosphorylation site {S80}
Ser phosphorylation site {S216}
Ser phosphorylation site {S218}
Ser phosphorylation site {S281}
Ser phosphorylation site {S317}
Ser phosphorylation site {S321}
Ser phosphorylation site {S393}
Ser phosphorylation site {S431}
Ser phosphorylation site {S436}
Thr phosphorylation site {T453}
Ser phosphorylation site {S455}
kinase domain
SITE: 525-791
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 531-539
ATP-binding site
NAME: ATP-binding site
SITE: 553-553
aspartate residue {D647}
Ser phosphorylation site {S821}
Ser phosphorylation site {S824}
Database Correlations
OMIM 604092
UniProt P33981
Pfam PF00069
Entrez Gene 7272
Kegg hsa:7272
ENZYME 2.7.12.1
References
UniProt :accession P33981