dual specificity protein kinase CLK4; CDC-like kinase 4 (CLK4)

Function: - dual specificity kinase - phosphorylates both Ser/Thr & Tyr-containing substrates - phosphorylates Ser & Arg-rich proteins of the spliceosomal complex & may be a constituent of a network of regulatory mechanisms that enable Ser & Arg-rich proteins to control RNA splicing - phosphorylates SRSF1 & SRSF3 - required for regulation of alternative splicing of MAPT/TAU - regulates alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells - TG003 inhibits its kinase activity & affects regulation of alternative splicing mediated by phosphorylation of Ser & Arg-rich proteins (putative) - autophosphorylates on Ser, Thr & Tyr - interacts with UBL5 Structure: - belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, lammer subfamily - contains 1 protein kinase domain Compartment: nucleus (putative) Expression: - expressed in liver, kidney, heart, muscle, brain & endothelial cells

General

nuclear protein serine/threonine kinase tyrosine kinase (protein tyrosine kinase, PTK)

Properties

SIZE: entity length = 481 aa MW = 57 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S136} Ser phosphorylation site {S138} kinase domain SITE: 159-475 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 165-173 ATP-binding site NAME: ATP-binding site SITE: 189-189 aspartate residue {D286} STATE: active state

Database Correlations

OMIM 607969 UniProt Q9HAZ1 Pfam PF00069 Entrez Gene 57396 Kegg hsa:57396 ENZYME 2.7.12.1

References

UniProt :accession Q9HAZ1