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dual specificity protein phosphatase 2, phosphatase of activated cells-1 (PAC-1); mitogen-induced nuclear tyrosine phosphatase
Function:
- regulates mitogenic signal transduction by dephosphorylating both Thr & Tyr residues on MAP kinases ERK1 & ERK2
- specificity for MAP kinase (s)
protein tyrosine phosphate + H2O protein tyrosine + phosphate
phosphoprotein + H2O protein + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
- contains 1 rhodanese domain contains 1 tyrosine-protein phosphatase domain
Compartment: nucleus
Expression:
- expressed in hematopoietic tissues
- induced by mitogens
- transiently expressed during G1 & constitutively expressed in T-cells infected with HTLV-1
General
dual specificity phosphatase
nuclear protein
Properties
SIZE: MW = 32 kD
entity length = 314 aa
COMPARTMENT: cell nucleus
CELL: blood cell
MOTIF: cysteine residue {N-TERMINAL} (10)
active site
MOTIF: HC motif
active site
cysteine residue {C-TERMINAL} (2)
STATE: active state
Database Correlations
OMIM 603068
UniProt Q05923
Pfam PF00581
Entrez Gene 1844
ENZYME correlations
References
- Rohan PJ, Davis P, Moskaluk CA, Kearns M, Krutzsch H,
Siebenlist U, Kelly K.
PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase.
Science. 1993 Mar 19;259(5102):1763-6.
PMID: 7681221
- Nebreda AR.
Inactivation of MAP kinases.
Trends Biochem Sci. 1994 Jan;19(1):1-2. Review.
PMID: 8140614
- Ward Y, Gupta S, Jensen P, Wartmann M, Davis RJ, Kelly K.
Control of MAP kinase activation by the mitogen-induced
threonine/tyrosine phosphatase PAC1.
Nature. 1994 Feb 17;367(6464):651-4.
PMID: 8107850
- UniProt :accession Q05923