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dual oxidase maturation factor 2 (dual oxidase activator 2, DUOXA2)
Function:
- required for maturation & transport of DUOX2 from endoplasmic reticulum to plasma membrane
- role in thyroid hormone synthesis (putative)
Structure:
- belongs to the DUOXA family
- N-glycosylated
Compartment: endoplasmic reticulum membrane
Expression:
- specifically expressed in thyroid
- also detected in salivary glands
General
chaperonin; chaperone
glycoprotein
transmembrane 5 protein
Properties
SIZE: MW = 35 kD
entity length = 320 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: exoplasmic domain {1-21}
transmembrane domain {22-42}
cytoplasmic loop {43-56}
transmembrane domain {57-77}
exoplasmic loop {78-183}
MOTIF: N-glycosylation site {N84}
N-glycosylation site {N109}
N-glycosylation site {N121}
transmembrane domain {184-204}
cytoplasmic loop {205-206}
transmembrane domain {207-227}
exoplasmic loop {228-247}
transmembrane domain {248-268}
cytoplasmic domain {269-320}
Database Correlations
UniProt Q1HG44
References
UniProt :accession Q1HG44