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dual oxidase maturation factor 1 (dual oxidase activator 1, Numb-interacting protein, DUOXA1, NIP, NUMBIP)
Function:
- may be required for maturation & transport of DUOX1 from endoplasmic reticulum to plasma membrane
- may interact with NUMB
Structure: belongs to the DUOXA family
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- specifically expressed in thyroid gland
- also detected in esophagus
Related
dual oxidase maturation factor (DUOXA)
General
chaperonin; chaperone
glycoprotein
transmembrane 5 protein
Properties
SIZE: MW = 38 kD
entity length = 343 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-24}
transmembrane domain {25-45}
cytoplasmic loop {46-51}
transmembrane domain {52-72}
exoplasmic loop {73-183}
MOTIF: N-glycosylation site {N84}
N-glycosylation site {N109}
N-glycosylation site {N121}
transmembrane domain {184-204}
cytoplasmic loop {205-206}
transmembrane domain {207-227}
exoplasmic loop {228-249}
transmembrane domain {250-270}
cytoplasmic domain {271-343}
Database Correlations
UniProt Q1HG43
References
UniProt :accession Q1HG43