dual oxidase 2; large NOX 2; long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; thyroid oxidase 2; p138 thyroid oxidase (DUOX2 LNOX2 THOX2)

Function: 1) generates hydrogen peroxide required for activity of thyroid peroxidase lactoperoxidase 2) thyroid hormones synthesis 3) lactoperoxidase-mediated antimicrobial defense at the surface of mucosa 4) may have intrinsic peroxidase activity through N-terminal peroxidase-like domain 5) NADPH oxidase activity is Ca⁺²-dependent. 6) interacts with TXNDC11, TPO, CYBA Structure: - N-glycosylated - in the N-terminal section; belongs to the peroxidase family - contains 3 EF-hand domains - contains 1 FAD-binding FR-type domain - contains 1 ferric oxidoreductase domain Compartment: - localizes to the apical membrane of epithelial cells Expression: - expressed in colon, small intestine, duodenum, tracheal surface epithelial cells, thyrocytes, kidney, liver, lung, pancreas, prostate, salivary glands, rectum, testis - widely expressed in fetal tissues - induction by forskolin, thyrotropin, Th1-specific IFN gamma Pathology: - defects in DUOX2 are a cause of congenital hypothyroidism

General

Ca+2 binding protein glycoprotein oxidoreductase transmembrane 7 protein

Properties

SIZE: MW = 175 kD entity length = 1548 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-601} MOTIF: signal sequence {1-25} Peroxidase-like {30-596} N-glycosylation site {N100} N-glycosylation site {N348} N-glycosylation site {N382} N-glycosylation site {N455} N-glycosylation site {N537} transmembrane domain {602-622} cytoplasmic loop {623-1041} MOTIF: EF hand SITE: 819-854 EF hand SITE: 855-890 EF hand SITE: 899-934 transmembrane domain {1042-1062} exoplasmic loop {1063-1076} transmembrane domain {1077-1097} cytoplasmic loop {1098-1148} transmembrane domain {1149-1169} exoplasmic loop {1170-1185} transmembrane domain {1186-1206} cytoplasmic loop {1207-1223} transmembrane domain {1224-1244} exoplasmic loop {1245-1244} transmembrane domain {1245-1265} cytoplasmic domain {1266-1548}

Database Correlations

OMIM correlations UniProt Q9NRD8 PFAM correlations Entrez Gene 50506 Kegg hsa:50506 ENZYME correlations

References

UniProt :accession Q9NRD8