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dual oxidase 1; large NOX 1; long NOX 1; NADPH thyroid oxidase 1; thyroid oxidase 1 (DUOX1, DUOX, LNOX1, THOX1)
Function:
1) generates hydrogen peroxide required for activity of thyroid peroxidase lactoperoxidase
2) thyroid hormones synthesis
3) lactoperoxidase-mediated antimicrobial defense at the surface of mucosa
4) may have intrinsic peroxidase activity through N-terminal peroxidase-like domain
5) NADPH oxidase activity is Ca+2-dependent.
6) interacts with TXNDC11, TPO, CYBA
Structure:
- N-glycosylated
- in the N-terminal section; belongs to the peroxidase famiily
- contains 3 EF-hand domains
- contains 1 FAD-binding FR-type domain
- contains 1 ferric oxidoreductase domain
Compartment:
- localizes to the apical membrane of epithelial cells
Alternative splicing: named isoforms=2
Expression:
- expressed in thyrocytes, tracheal surface epithelial cells, thyroid, trachea, bronchium > placenta, testis, prostate, pancreas, heart
- widely expressed in fetal tissues
- induction by forskolin, thyrotropin, IL-4, IL-13
General
Ca+2 binding protein
glycoprotein
oxidoreductase
transmembrane 7 protein
Properties
SIZE: MW = 177 kD
entity length = 1551 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-596}
MOTIF: signal sequence {1-21}
Peroxidase-like {26-593}
N-glycosylation site {N94}
N-glycosylation site {N342}
N-glycosylation site {N354}
N-glycosylation site {N461}
N-glycosylation site {N534}
transmembrane domain {597-617}
cytoplasmic loop {618-1044}
MOTIF: EF hand
SITE: 815-850
EF hand
SITE: 851-886
EF hand
SITE: 895-930
transmembrane domain {1045-1065}
exoplasmic loop {1066-1080}
transmembrane domain {1081-1101}
cytoplasmic loop {1102-1148}
transmembrane domain {1149-1171}
exoplasmic loop {1172-1188}
transmembrane domain {1189-1209}
cytoplasmic loop {1210-1226}
transmembrane domain {1227-1247}
exoplasmic loop {1248-1248}
transmembrane domain {1249-1269}
cytoplasmic domain {1270-1551}
Database Correlations
OMIM 606758
UniProt Q9NRD9
PFAM correlations
Entrez Gene 53905
Kegg hsa:53905
ENZYME correlations
References
UniProt :accession Q9NRD9