drug-nutrient interactions

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drug-nutrient interactions

Etiology: Antacids - NaHCO3, aluminum hydroxide) - folate, phosphate, Ca⁺², copper deficiency Anticonvulsants - phenytoin, phenobarbital, primidone - vitamin D, vitamin K & folate deficiency - valproate -> carnitine deficiency Antibiotics - tetracycline -> Ca⁺² deficiency - gentamcin -> K⁺, Mg⁺² deficiency - neomycin -> fat malabsorption, nitrogen depletion - trimethoprim -> folate deficiency - isoniazid -> vitamin B6, niacin, vitamin D deficiency Antibacterial agents - boric acid -> riboflavin deficiency Antimalarials - pyrimethamine -> folate deficiency Anti-inflammatory agents - sulfasalazine -> folate deficiency - colchicine -> fat malabsorption, vitamin B12 deficiency - NSAIDs, aspirin -> iron deficiency - glucocorticoids -> vitamin D, Ca⁺² deficiency Antineoplastic agents - methotrexate -> folate, Ca⁺² deficiency - cisplatin -> Mg⁺² deficiency Anticoagulants - warfarin -> vitamin K deficiency Antihypertensive agents - hydralazine -> vitamin B6 deficiency Diuretics: - thiazides -> K⁺ deficiency, Mg⁺² deficiency - furosemide -> K⁺, Ca+, Mg⁺² deficiency - triamterene -> folate deficiency H2-receptor antagonists - cimetidine, ranitidine, famotidine -> vitamin B12, folate, vitamin C, zinc deficiency Hypolipidemic agents - cholestyramine -> fat malabsorption - colestipol - vitamin K, vitamin A, folate, vitamin B12 deficiency Laxatives: - mineral oil -> vitamin A, vitamin D, vitamin K deficiency - Senna -> fat malabsorption, K⁺, Ca+ deficiency Proton pump inhibitors - omeprazole - vitamin B12, folate, Ca⁺², vitamin C, zinc deficiency Tranquilizers - chlorpromazine -> riboflavin deficiency

disease-nutrition interactions nutrition

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drug interaction

References

Fiatarone Singh MA & Rosenberg IH, Nutrition and Aging, In: Principles of Geriatric Medicine, 4th ed,, Hazzard et al (eds), McGraw-Hill, NY, 1999, pg 92

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