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drug interaction(s) of fluticasone with HIV1 protease inhibitors

Drug interactions: - patients using fluticasone with HIV1 protease inhibitor (ritonavir) risk iatrogenic Cushing's syndrome due to inhibition of CYPA4 by ritonavir further increasing 1/2life of fluticasone & serum levels [1,2] Management: - replace fluticasone with beclomethasone or budesonide as these glucocorticoids are safer to use with HIV1 protease inhibitors (ritonavir) [1,2]

Properties

DRUGS: fluticasone protease inhibitor

References

  1. Foisy MM, Yakiwchuk EM, Chiu I, Singh AE. Adrenal suppression and Cushing's syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature. HIV Med. 2008 Jul;9(6):389-96. PMID: 18459946 Free article
  2. NEJM Knowledge+ Complex Medical Care