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drug interaction(s) SGLT2 inhibitors (flozins) with diuretics
Drug interactions:
- SGLT2 inhibitors (flozins) increase the hypotensive & hypovolemic effects of diuretics [1]
- discontinue diuretic if signs of hypotension & hypovolemia [3]
Properties
DRUGS: SGLT-2 inhibitor
diuretic
References
- Baker WL, Smyth LR, Riche DM, Bourret EM, Chamberlin KW, White WB.
Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure:
a systematic review and meta-analysis.
J Am Soc Hypertens. 2014 Apr;8(4):262-75.e9.
PMID: 24602971 Review.
- Dubrofsky L, Srivastava A, Cherney DZ
Sodium-Glucose Cotransporter-2 Inhibitors in Nephrology Practice: A Narrative Review.
Can J Kidney Health Dis. 2020 Jun 24;7:2054358120935701.
PMID: 32637144 PMCID: PMC7315675 Free PMC article. Review.
- NEJM Knowledge+ Endocrinology