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drug interaction(s) of calcineurin inhibitors with ACE inhibitors
Drug interactions:
- coadministration of ACE inhibitor or ARB with aldosterone antagonist associated with risk of hyperkalemia
- risk for severe hyperkalemia is lower with coadministration of sacubitril/valsartan than with enalapril [1]
Properties
DRUGS: aldosterone receptor antagonist
ACE inhibitor
References
- Desai AS, Vardeny O, Claggett B et al
Reduced Risk of Hyperkalemia During Treatment of Heart Failure
With Mineralocorticoid Receptor Antagonists by Use of Sacubitril/
Valsartan Compared With Enalapril. A Secondary Analysis of the
PARADIGM-HF Trial.
JAMA Cardiol. Published online November 14, 2016
PMID: 27842179
http://jamanetwork.com/journals/jamacardiology/article-abstract/2583456
- Ezekowitz JA
Hyperkalemia, Sacubitril/Valsartan, and Mineralocorticoid
Antagonists in Patients With Heart Failure.
JAMA Cardiol. Published online November 14, 2016
PMID: 27842180
http://jamanetwork.com/journals/jamacardiology/article-abstract/2583455