Search
drug interaction(s) of sofosbuvir with amiodarone
Drug interactions:
- combination of sofosbuvir with amiodarone associated with 9 cases of symptomatic bradycardia with 1 fatal cardiac arrest [1]
Properties
DRUGS: sofosbuvir
amiodarone
References
- Gilead Sciences, Inc. 3/20/2015
IMPORTANT DRUG WARNING
Subject: Serious and Life-Threatening Cases of Symptomatic
Bradycardia as well as one Case of Fatal Cardiac Arrest
Reported with Coadministration of Amiodarone with either
Harvoni (ledipasvir and sofosbuvir fixed-dose combination)
or with Sovaldi (sofosbuvir) in combination with another
Direct Acting Antiviral.
http://freepdfhosting.com/47b90580b3.pdf
- FDA Safety Alert, March 24, 2015
Hepatitis C Treatments Containing Sofosbuvir in Combination
With Another Direct Acting Antiviral Drug: Drug Safety
Communication - Serious Slowing of Heart Rate When Used With
Antiarrhythmic Drug Amiodarone.
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm439662.htm