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drug interaction(s) of digoxin in combination with macrolides

Drug interactions: - macrolides (at least erythromycin, clarithromycin) inhibit P-glycoprotein mediated efflux mechanisms of digoxin & increase risk of digoxin toxicity [1,2]

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DRUGS: digoxin macrolide

References

  1. Hines LE, Murphy JE. Potentially harmful drug-drug interactions in the elderly: a review. Am J Geriatr Pharmacother. 2011 Dec;9(6):364-77 PMID: 22078863
  2. Lee CY, Marcotte F, Giraldeau G, Koren G, Juneau M, Tardif JC. Digoxin toxicity precipitated by clarithromycin use: case presentation and concise review of the literature. Can J Cardiol. 2011 Nov-Dec;27(6):870.e15-6. Epub 2011 Sep 9. PMID: 21907534