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drug interaction(s) of calcium channel blockers with ARBs

Drug interactions: - diuretics (including loop diuretics) are ineffective in treating calcium channel blocker (CCB)-induced edema [1] - CCB-induced edema is due to arteriolar vasodilation rather than excess plasma volume - ACE inhibitors & ARBs can counteract CCB-induced edema - CCB-induced arteriolar vasodilation causes edema by increasing capillary pressure - ACE inhibitors or ARBs can lower that increased capillary pressure by decreasing postcapillary resistance [2]

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DRUGS: calcium channel blocker angiotensin II receptor antagonist

References

  1. Rochon PA et al. Association of a calcium channel blocker and diuretic prescribing cascade with adverse events: A population-based cohort study. J Am Geriatr Soc 2024 Feb; 72:467. PMID: 38009803 https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.18683
  2. Makani H, Bangalore S, Romero J, Wever-Pinzon O, Messerli FH. Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker- Associated Peripheral Edema. Am J Med. 2011 Feb;124(2):128-35 PMID: 21295192 https://www.amjmed.com/article/S0002-9343(10)00745-X/fulltext