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drug interaction(s) of calcium channel blockers with ACE inhibitors
Drug interactions:
- diuretics (including loop diuretics) are ineffective in treating calcium channel blocker (CCB)-induced edema [1]
- CCB-induced edema is due to arteriolar vasodilation rather than excess plasma volume
- ACE inhibitors & ARBs can counteract CCB-induced edema
- CCB-induced arteriolar vasodilation causes edema by increasing capillary pressure
- ACE inhibitors or ARBs can lower that increased capillary pressure by decreasing postcapillary resistance [2]
Properties
DRUGS: calcium channel blocker
ACE inhibitor
References
- Rochon PA et al.
Association of a calcium channel blocker and diuretic prescribing cascade
with adverse events: A population-based cohort study.
J Am Geriatr Soc 2024 Feb; 72:467.
PMID: 38009803
https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.18683
- Makani H, Bangalore S, Romero J, Wever-Pinzon O, Messerli FH.
Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-
Associated Peripheral Edema.
Am J Med. 2011 Feb;124(2):128-35
PMID: 21295192
https://www.amjmed.com/article/S0002-9343(10)00745-X/fulltext