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drug interaction(s) of calcium channel blockers with clarithromycin

Drug interactions: - clarithromycin, a potent inhibitor of cyt P450 3A4 can significantly increase plasma levels of calcium channel blockers - older patients may end up in hospital with hypotension or shock - reports of edema, arrythmias or heart block - combination linked to acute renal failure (RR=2) [2]

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DRUGS: calcium channel blocker clarithromycin

References

  1. Prescriber's Letter 18(3): 2011 COMMENTARY: Calcium Channel Blocker-Macrolide Interaction Detail-Document#: 270307 (subscription needed) http://www.prescribersletter.com
  2. Gandhi S et al Calcium-channel blocker - Clarithromycin Drug Interactions and Acute Kidney Injury. JAMA. Published online November 09, 2013 PMID: 24346990 http://jama.jamanetwork.com/article.aspx?articleid=1769739