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drug interaction(s) of aspirin, clopidogrel & warfarin
Drug interactions:
- relative risk of hemorrage relative to monotherapy with warfarin
a) aspirin 0.96
b) clopidogrel 1.33
c) clopidogrel + aspirin 1.47
d) warfarin + aspirin 1.75
- ref [2] gives a much higher relative risk (7.3)
e) warfarin + clopidogrel 3.57
f) warfarin + clopidogrel + aspirin 4.03
Properties
DRUGS: APRIRIN
clopidogrel
warfarin
References
- Hansen ML et al
Risk of Bleeding With Single, Dual, or Triple Therapy With
Warfarin, Aspirin, and Clopidogrel in Patients With Atrial
Fibrillation
Arch Intern Med. 2010;170(16):1433-1441.
PMID: 20837828
http://archinte.ama-assn.org/cgi/content/short/170/16/1433
- Hamon M et al.
Incidence, source, determinants, and prognostic impact of major
bleeding in outpatients with stable coronary artery disease.
J Am Coll Cardiol 2014 Oct 7; 64:1430.
PMID: 25277612
- Dauerman HL.
Reconsidering the necessity of aspirin in stable coronary
artery disease.
J Am Coll Cardiol 2014 Oct 7; 64:1437
PMID: 25277613