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drug interaction(s) of renin-angiotensin-aldosterone inhibitors with trimethoprim-sulfamethoxazole
Drug interactions:
- combination may increase risk of
- hyperkalemia
- it seems as if trimethoprim-sulfamethoxazole is alone among antibiotics in this interaction with renin-angiotensin inhibitors
- increased risk of hyperkalemia & sudden death in elderly taking ACE inhibitors or ARBs [2]
- RR=1.38, absolute risk increase 0.2% [2]
Properties
DRUGS: renin-angiotensin-aldosterone system inhibitor
trimethoprim/sulfamethoxazole
References
- Antoniou T et al.
Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients
receiving inhibitors of the renin-angiotensin system:
A population-based study.
Arch Intern Med 2010 Jun 28; 170:1045.
PMID: 20585070
- Fralick M et al
Co-trimoxazole and sudden death in patients receiving
inhibitors of renin-angiotensin system: population based
study.
BMJ 2014;349:g6196
PMID: 25359996
http://www.bmj.com/content/349/bmj.g6196
- Etminan M, Brophy JM
Antibiotics and sudden death in adults taking renin-
angiotensin system blockers.
BMJ 2014;349:g6242
PMID: 25360034
http://www.bmj.com/content/349/bmj.g6242